Background data of 2-year-old male and female F344 <i>gpt</i> delta rats

Metabolism and disposition of phenolphthalein in male and female F344 rats and B6C3F1 mice.

A recent 2-year carcinogenicity/toxicology study determined that phenolphthalein (PHTH) is a multisite carcinogen in both mice and rats at all doses evaluated. In response to this finding the metabolism and disposition of PHTH has been evaluated in both F344 rats and B6C3F1 mice at a single oral dose of 800 mg/kg. This dose fell within the range previously found to be carcinogenic in rats and m...

Kidney and liver distribution of ochratoxin A in male and female F344 rats.

The impact of age and gender on Ochratoxin A (OTA) distribution in kidney and liver were studied. OTA was quantified in kidney and liver of young and mature rats of both sexes. Data was fit simultaneously using the population approach with NONMEM program. Fed and fasted mature males showed a 30% decrease and an 11% increase in relative bioavailability, respectively, in comparison with the rest ...

L-Deprenyl reverses age-associated decline in splenic norepinephrine, interleukin-2 and interferon-γ production in old female F344 rats.

UNLABELLED Aging in female rats is associated with cessation of reproductive cycles, development of mammary cancer, and increased incidence of autoimmune diseases. Previously, we demonstrated an age-related decline in sympathetic noradrenergic (NA) innervation in the spleen and lymph nodes of female F344 rats accompanied by significantly reduced natural killer cell activity, interleukin (IL)-2 ...

A 2-year-old female with Fever and rash.

Basophil adenomata in the pituitary glands of 2-year-old male Long-Evans rats.

Pituitaries of male and female Long-Evans rats were examined two years after internal or external thyroid radiation. Treatment with radioiodine significantly increased the num bers of thyrotropic pituitary cell adenomata in both sexes. No increase in the numbers of such adenomata followed the X-irradiation of the male thyroid glands in the doses used. Gonadotropic cell adenomata were found in 7...